Pardis Sabeti

Dr. Pardis Sabeti is an Assistant Professor at the Center for Systems Biology at Harvard University, Department of Organismic and Evolutionary Biology, and a Senior Associate Member of the Broad Institute of Harvard and MIT. Dr. Sabeti is a computational geneticist with expertise studying genetic diversity, developing algorithms to detect genetic signatures of natural selection, and carrying out genetic association studies. Sabeti completed her undergraduate degree at MIT and continued her education at Oxford as a Rhodes Scholar, before returning to earn her medical degree from Harvard Medical School as a Soros Fellow where she was only the third woman to graduate summa cum laude. Her graduate work at Oxford University focused on host genetic factors in Plasmodium falciparum malaria susceptibility and studying patterns of genetic diversity to identify rapidly evolving genes. At Harvard, she has developed novel methods to detect natural selection, and applied it to the entire human genome, finding many new evidence of human evolution.

Dr. Sabeti is currently supported by a Burroughs Wellcome Fund Career Award, a Packard Foundation Fellowship in Science and Engineering, and an NIH Innovator award, and awards from NIAID, TMTI, and the Gates Foundation. Dr. Sabeti is also the lead singer of the alternative rock band Thousand Days.

Human evolutionary genomics: ethical and interpretive issues. Trends Genet. [Epub ahead of print]
Joseph J. Vitti, Mildred K. Cho, Sarah A. Tishkoff, Pardis C. Sabeti

Detecting novel associations in large datasets.
Science 334:1518-1524
David N. Reshef, Yakir A. Reshef, Hilary K. Finucane, Sharon R. Grossman, Gilean McVean, Peter J. Turnbaugh, Eric S. Lander, Michael Mitzenmacher, Pardis C. Sabeti

A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biol 12(6): R56.

Kate M. Broadbent, Daniel Park, Ashley R. Wolf, Daria Van Tyne, Jennifer S. Sims, Ulf Ribacke, Sarah Volkman, Manoj Duraisingh, Dyann Wirth, Pardis C. Sabeti and John L. Rinn

Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet 7(4): e1001383.
Daria Van Tyne, Daniel J. Park, Stephen F. Schaffner, Daniel E. Neafsey, Elaine Angelino, Joseph F. Cortese, Kayla G. Barnes, David M. Rosen, Amanda K. Lukens, Rachel F. Daniels, Danny A. Milner Jr, Charles A. Johnson, Ilya Shlyakhter, Sharon R. Grossman, Justin S. Becker, Daniel Yamins, Elinor K. Karlsson, Daouda Ndiaye, Ousmane Sarr, Souleymane Mboup, Christian Happi, Nicholas A. Furlotte, Eleazar Eskin, Hyun Min Kang, Daniel L. Hartl, Bruce W. Birren, Roger C. Wiegand, Eric S. Lander, Dyann F. Wirth, Sarah K. Volkman, Pardis C. Sabeti.

A composite of multiple signals distinguishes causal variants in regions of positive selection .
Science 327:883-886
Sharon R. Grossman, Ilya Shylakhter, Elinor K. Karlsson, Elizabeth H. Byrne, Shannon Morales, Gabriel Frieden, Elizabeth Hostetter, Elaine Angelino, Manuel Garber, Or Zuk, Eric S. Lander, Stephen F. Schaffner, Pardis C. Sabeti

Detecting recent positive selection in the human genome from haplotype structure.
Nature 419:832-837
Pardis C. Sabeti, David E. Reich, John M. Higgins, Haninah Z. P. Levine, Daniel J. Richter, Stephen F. Schaffner, Stacey B. Gabriel, Jill V. Platko, Nick J. Patterson, Gavin J. McDonald, Hans C. Ackerman, Sarah J. Campbell, David Altshuler, Richard Cooper, Dominic Kwiatkowski, Ryk Ward & Eric S. Lander.



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