Pardis Sabeti
Dr. Pardis Sabeti is an Associate Professor at the Center for Systems Biology at Harvard University, Department of Organismic and Evolutionary Biology, and in the Department of Immunology and Infectious Disease at Harvard School of Public Health, and is a Senior Associate Member of the Broad Institute of Harvard and MIT.
Dr. Sabeti is a computational geneticist with expertise studying genetic diversity, developing algorithms to detect genetic signatures of natural selection, and carrying out genetic association studies. She completed her undergraduate degree at MIT and her PhD at Oxford as a Rhodes Scholar, before returning to earn her medical degree from Harvard Medical School as a Soros Fellow. Dr. Sabeti’s lab focuses on detecting and characterizing signals of natural selection in humans and pathogens.
Dr. Sabeti is supported by a Burroughs Wellcome Fund Career Award, a Packard Foundation Fellowship in Science and Engineering, and an NIH Innovator award, and awards from NIAID, TMTI, and the Gates Foundation. Dr. Sabeti is a World Economic Forum Young Global Leader, a PopTech Science Fellow, and is the lead singer of the alternative rock band Thousand Days.
Human evolutionary genomics: ethical and interpretive issues. Trends Genet.
Joseph J. Vitti, Mildred K. Cho, Sarah A. Tishkoff, Pardis C. Sabeti
Detecting novel associations in large datasets.
Science 334:1518-1524
David N. Reshef, Yakir A. Reshef, Hilary K. Finucane, Sharon R. Grossman, Gilean McVean, Peter J. Turnbaugh, Eric S. Lander, Michael Mitzenmacher, Pardis C. Sabeti
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biol 12(6): R56.
Kate M. Broadbent, Daniel Park, Ashley R. Wolf, Daria Van Tyne, Jennifer S. Sims, Ulf Ribacke, Sarah Volkman, Manoj Duraisingh, Dyann Wirth, Pardis C. Sabeti and John L. Rinn
Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet 7(4): e1001383.
Daria Van Tyne, Daniel J. Park, Stephen F. Schaffner, Daniel E. Neafsey, Elaine Angelino, Joseph F. Cortese, Kayla G. Barnes, David M. Rosen, Amanda K. Lukens, Rachel F. Daniels, Danny A. Milner Jr, Charles A. Johnson, Ilya Shlyakhter, Sharon R. Grossman, Justin S. Becker, Daniel Yamins, Elinor K. Karlsson, Daouda Ndiaye, Ousmane Sarr, Souleymane Mboup, Christian Happi, Nicholas A. Furlotte, Eleazar Eskin, Hyun Min Kang, Daniel L. Hartl, Bruce W. Birren, Roger C. Wiegand, Eric S. Lander, Dyann F. Wirth, Sarah K. Volkman, Pardis C. Sabeti.
Genome-sequencing Anniversary. The landscape of human evolution. Science 311:6018.
Pardis C Sabeti.
A composite of multiple signals distinguishes causal variants in regions of positive selection .
Science 327:883-886
Sharon R. Grossman, Ilya Shylakhter, Elinor K. Karlsson, Elizabeth H. Byrne, Shannon Morales, Gabriel Frieden, Elizabeth Hostetter, Elaine Angelino, Manuel Garber, Or Zuk, Eric S. Lander, Stephen F. Schaffner, Pardis C. Sabeti
Detecting recent positive selection in the human genome from haplotype structure.
Nature 419:832-837
Pardis C. Sabeti, David E. Reich, John M. Higgins, Haninah Z. P. Levine, Daniel J. Richter, Stephen F. Schaffner, Stacey B. Gabriel, Jill V. Platko, Nick J. Patterson, Gavin J. McDonald, Hans C. Ackerman, Sarah J. Campbell, David Altshuler, Richard Cooper, Dominic Kwiatkowski, Ryk Ward & Eric S. Lander.
