Pardis Sabeti

Dr. Pardis Sabeti is an Associate Professor at the Center for Systems Biology at Harvard University, Department of Organismic and Evolutionary Biology, and in the Department of Immunology and Infectious Disease at Harvard School of Public Health, and is a Senior Associate Member of the Broad Institute of Harvard and MIT.

Dr. Sabeti is a computational geneticist with expertise studying genetic diversity, developing algorithms to detect genetic signatures of natural selection, and carrying out genetic association studies. She completed her undergraduate degree at MIT and her PhD at Oxford as a Rhodes Scholar, before returning to earn her medical degree from Harvard Medical School as a Soros Fellow. Dr. Sabeti’s lab focuses on detecting and characterizing signals of natural selection in humans and pathogens.

Dr. Sabeti is supported by a Burroughs Wellcome Fund Career Award, a Packard Foundation Fellowship in Science and Engineering, and an NIH Innovator award, and awards from NIAID, TMTI, and the Gates Foundation. Dr. Sabeti is a World Economic Forum Young Global Leader, a PopTech Science Fellow, National Geographic Emerging Explorer, and is the lead singer of the alternative rock band Thousand Days.

Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science. 2014.
Gire SK, Goba A, Andersen KG, Sealfon RS, Park DJ, Kanneh L, Jalloh S, Momoh M, Fullah M, Dudas G, Wohl S, Moses LM, Yozwiak NL, Winnicki S, Matranga CB, Malboeuf CM, Qu J, Gladden AD, Schaffner SF, Yang X, Jiang PP, Nekoui M, Colubri A, Coomber MR, Fonnie M, Moigboi A, Gbakie M, Kamara FK, Tucker V, Konuwa E, Saffa S, Sellu J, Jalloh AA, Kovoma A, Koninga J, Mustapha I, Kargbo K, Foday M, Yillah M, Kanneh F, Robert W, Massally JL, Chapman SB, Bochicchio J, Murphy C, Nusbaum C, Young S, Birren BW, Grant DS, Scheiffelin JS, Lander ES, Happi C, Gevao SM, Gnirke A, Rambaut A, Garry RF, Khan SH, Sabeti PC.

Natural selection in a bangladeshi population from the cholera-endemic ganges river delta. Science Translational Medicine 2013.
Karlsson EK, Harris JB, Tabrizi S, Rahman A, Shlyakhter I, Patterson N, O'Dushlaine C, Schaffner SF, Gupta S, Chowdhury F, Sheikh A, Shin OS, Ellis C, Becker CE, Stuart LM, Calderwood SB, Ryan ET, Qadri F, Sabeti PC, Larocque RC.

The adaptive variant EDARV370A is associated with straight hair in East Asians. Human Genetics 2013.
Tan J, Yang Y, Tang K, Sabeti PC, Jin L, Wang S.

Identifying recent adaptations in large-scale genomic data. Cell 2013.
Grossman SR, Andersen KG, Shlyakhter I, Tabrizi S, Winnicki S, Yen A, Park DJ, Griesemer D, Karlsson EK, Wong SH, Cabili M, Adegbola RA, Bamezai RN, Hill AV, Vannberg FO, Rinn JL, Lander ES, Schaffner SF, Sabeti PC.

Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell 2013.
Kamberov YG, Wang S, Tan J, Gerbault P, Wark A, Tan L, Yang Y, Li S, Tang K, Chen H, Powell A, Itan Y, Fuller D, Lohmueller J, Mao J, Schachar A, Paymer M, Hostetter E, Byrne E, Burnett M, McMahon AP, Thomas MG, Lieberman DE, Jin L, Tabin CJ, Morgan BA, Sabeti PC.

Many ways to die, one way to arrive: how selection acts through pregnancy. Trends in Genetics 2013.
Brown EA, Ruvolo M, Sabeti PC.

Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation. PLoS Negl Trop Dis 2012.
Asogun DA, Adomeh DI, Ehimuan J, Odia I, Hass M, Gabriel M, Olschläger S, Becker-Ziaja B, Folarin O, Phelan E, Ehiane PE, Ifeh VE, Uyigue EA, Oladapo YT, Muoebonam EB, Osunde O, Dongo A, Okokhere PO, Okogbenin SA, Momoh M, Alikah SO, Akhuemokhan OC, Imomeh P, Odike MA, Gire S, Andersen K, Sabeti PC, Happi CT, Akpede GO, Günther S.

High depth, whole-genome sequencing of cholera isolates from Haiti and the Dominican Republic. BMC Genomics 2012.
Sealfon R, Gire S, Ellis C, Calderwood S, Qadri F, Hensley L, Kellis M, Ryan ET, LaRocque RC, Harris JB, Sabeti PC.

Emerging disease or diagnosis?. Science 2012.
Gire SK, Stremlau M, Andersen KG, Schaffner SF, Bjornson Z, Rubins K, Hensley L, McCormick JB, Lander ES, Garry RF, Happi C, Sabeti PC.

Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever. Phil. Trans. R. Soc. B 2012.
Kristian G Andersen, Ilya Shylakhter, Shervin Tabrizi, Shari R Grossman, Christian T Happi, Pardis C Sabeti

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. PNAS 2012.
Daniel J. Park, Amanda K. Lukensa, Daniel E. Neafsey, Stephen F. Schaffner, Hsiao-Han Chang, Clarissa Valim, Ulf Ribacke, Daria Van Tyne, Kevin Galinsky, Meghan Galligan, Justin S. Becker, Daouda Ndiaye, Souleymane Mboup, Roger C. Wiegand, Daniel L. Hartl, Pardis C. Sabeti, Dyann F. Wirth, and Sarah K. Volkman

Human evolutionary genomics: ethical and interpretive issues. Trends Genet.
Joseph J. Vitti, Mildred K. Cho, Sarah A. Tishkoff, Pardis C. Sabeti

Detecting novel associations in large datasets.
Science 334:1518-1524
David N. Reshef, Yakir A. Reshef, Hilary K. Finucane, Sharon R. Grossman, Gilean McVean, Peter J. Turnbaugh, Eric S. Lander, Michael Mitzenmacher, Pardis C. Sabeti

A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biol 12(6): R56.

Kate M. Broadbent, Daniel Park, Ashley R. Wolf, Daria Van Tyne, Jennifer S. Sims, Ulf Ribacke, Sarah Volkman, Manoj Duraisingh, Dyann Wirth, Pardis C. Sabeti and John L. Rinn

Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet 7(4): e1001383.
Daria Van Tyne, Daniel J. Park, Stephen F. Schaffner, Daniel E. Neafsey, Elaine Angelino, Joseph F. Cortese, Kayla G. Barnes, David M. Rosen, Amanda K. Lukens, Rachel F. Daniels, Danny A. Milner Jr, Charles A. Johnson, Ilya Shlyakhter, Sharon R. Grossman, Justin S. Becker, Daniel Yamins, Elinor K. Karlsson, Daouda Ndiaye, Ousmane Sarr, Souleymane Mboup, Christian Happi, Nicholas A. Furlotte, Eleazar Eskin, Hyun Min Kang, Daniel L. Hartl, Bruce W. Birren, Roger C. Wiegand, Eric S. Lander, Dyann F. Wirth, Sarah K. Volkman, Pardis C. Sabeti.

A composite of multiple signals distinguishes causal variants in regions of positive selection .
Science 327:883-886
Sharon R. Grossman, Ilya Shylakhter, Elinor K. Karlsson, Elizabeth H. Byrne, Shannon Morales, Gabriel Frieden, Elizabeth Hostetter, Elaine Angelino, Manuel Garber, Or Zuk, Eric S. Lander, Stephen F. Schaffner, Pardis C. Sabeti

Detecting recent positive selection in the human genome from haplotype structure.
Nature 419:832-837
Pardis C. Sabeti, David E. Reich, John M. Higgins, Haninah Z. P. Levine, Daniel J. Richter, Stephen F. Schaffner, Stacey B. Gabriel, Jill V. Platko, Nick J. Patterson, Gavin J. McDonald, Hans C. Ackerman, Sarah J. Campbell, David Altshuler, Richard Cooper, Dominic Kwiatkowski, Ryk Ward & Eric S. Lander.



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