Sun, Sep 5 , 2010

Education:

B.S. in Biology, MIT

M.Sc. in Human Biology, Oxford

D.Phil. in Biological Anthropology, Oxford

M.D. summa cum laude, Harvard Medical School



Dr. Pardis Sabeti is a starting Assistant Professor at Harvard University in the Center for Systems Biology and the Department of Organismic and Evolutionary Biology. Pardis graduated with an S.B. in Biology at MIT, an M.Sc. and D.Phil. at Oxford University, and an M.D. at Harvard Medical School, being the third woman ever to graduate summa cum laude.

In work published in Nature in 2002 with Professor Eric Lander, Pardis developed an approach to detect genes that are undergoing natural selection in the human genome. In her post-doctoral work she further developed analysis and software tools to study entire genomes. She has also been working with Dyann Wirth and colleagues at the Harvard School of Public Health to study the evolution of Plasmodium falciparum malaria. Pardis has published numerous papers in evolutionary genetics including first author publications in Nature, Science, and PLoS Biology.

Pardis's awards and fellowships include the Rhodes Scholarship, the Soros Fellowship, L'Oreal For Women in Science Fellowship, the Damon Runyon Cancer Foundation Post-doctoral fellowship, the Burroughs Wellcome Career Award in Biomedical Sciences, and the Packard Foundation Fellowship for Science and Engineering.

Pardis was named one of 8 Geniuses That will Change your Life by CNN.com, one of 100 Top Living Geniuses by the UK Daily Telegraph, a Science Spectrum Magazine Trailblazers, a Seed Magazine Revolutionary Mind, and a Genome Technology Tomorrow's PIs. Pardis served on the Board of Trustees of MIT from 1999-2004 and is on the SCR for Winthrop College at Harvard University. Pardis is also the lead singer and bassist of the alternative rock band Thousand Days.

Publications:
  1. Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, Ward R, Lander ES (2002) Detecting recent positive selection in the human genome from haplotype structure. Nature 419:832-837


  2. Bersaglieri T, Sabeti PC , Patterson N, Vanderploeg T, Schaffner SF, Drake JA, Rhodes M, Reich DE, Hirschhorn JN (2004) Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet 74:1111-1120


  3. The International Haplotype Map Consortium (2005) A haplotype map of the human genome. Nature 437:1299-1320


  4. Sabeti PC, Walsh E, Schaffner SF, Varilly P, Fry B, Hutcheson HB, Cullen M, Mikkelsen TS, Roy J, Patterson N, Cooper R, Reich D, Altshuler D, O'Brien S, Lander ES (2005) The case for selection at CCR5-Delta32. PLoS Biol 3:e378


  5. Sabeti PC, Schaffner SF, Fry B, Lohmueller J, Varilly P, Shamovsky O, Palma A, Mikkelsen TS, Altshuler D, Lander ES (2006) Positive natural selection in the human lineage. Science 312:1614-1620


  6. de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, Ke X, Monsuur AJ, Whittaker P, Delgado M, Morrison J, Richardson A, Walsh E C, Gao X, Galver L, Hart J, Hafler DA, Pericak-Vance M, Todd JA, Daly M J, Trowsdale J, Wijmenga C, Vyse T J, Beck S, Murray SS, Carrington M, Gregory S, Deloukas P, Rioux JD (2006) A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet 38:1166-1172


  7. Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Jr., Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, Waggoner S, Onofrio R, Ziaugra L, Mauceli E, Gnerre S, Jaffe DB, Zainoun J, Wiegand RC, Birren BW, Hartl DL, Galagan JE, Lander ES, Wirth DF (2007) A genome-wide map of diversity in Plasmodium falciparum. Nat Genet 39:113-119


  8. The International Haplotype Map Consortium (2007) A Phase 2 haplotype map of the human genome. Nature 449:851-61


  9. Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, Xie X, Byrne EH, McCarroll SA, Gaudet R, Schaffner SF, Lander ES, and The International Haplotype Map Consortium (2007) Genome-wide detection and characterization of positive selection in human populations. Nature 449:913-8