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AARON LIN

Aaron

Aaron Lin is currently a Ph.D. candidate in the Program in Virology at Harvard University, under the advisorship of Pardis Sabeti. His main focus is to gain insight into host-virus interactions through the use of experimental and computational approaches. His work draws upon Lassa and Ebola virus sequencing data as well as host transcriptomic data in response to infection. He hopes to someday merge virology with systems biology. His work is currently supported by a National Science Foundation Graduate Research Fellowship.

Previously, Aaron graduated summa cum laude from Princeton University with an A.B. in Molecular Biology in 2013. There, he conducted research in the lab of Ileana Cristea, studying protein-protein interactions by mass spectrometry during the herpesvirus life cycle. He demonstrated the first instance of a viral E3 ubiquitin ligase targeting a viral protein for proteasome-mediated degradation. He has also performed research in the lab of Mark Davis at Stanford University, studying T cell receptor binding affinities and the T cell response to influenza vaccination.

SELECTED PUBLICATIONS

Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013-2016 Epidemic.

Cell. 2016.
Diehl WE*, Lin AE*, Grubaugh ND*, Carvalho LM*, Kim K, Kyawe PP, McCauley SM, Donnard E, Kucukural A, McDonel P, Schaffner SF, Garber M, Rambaut A, Andersen KG, Sabeti PC, Luban J.

Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.

Cell. 2015.
Andersen KG, Shapiro BJ, Matranga CB, Sealfon R, Lin AE, Moses LM, Folarin OA, Goba A, Odia I, Ehiane PE, Momoh M, England EM, Winnicki S, Branco LM, Gire SK, Phelan E, Tariyal R, Tewhey R, Omoniwa O, Fullah M, Fonnie R, Fonnie M, Kanneh L, Jalloh S, Gbakie M, Saffa S, Karbo K, Gladden AD, Qu J, Stremlau M, Nekoui M, Finucane HK, Tabrizi S, Vitti JJ, Birren B, Fitzgerald M, McCowan C, Ireland A, Berlin AM, Bochicchio J, Tazon-Vega B, Lennon NJ, Ryan EM, Bjornson Z, Milner DA Jr, Lukens AK, Broodie N, Rowland M, Heinrich M, Akdag M, Schieffelin JS, Levy D, Akpan H, Bausch DG, Rubins K, McCormick JB, Lander ES, Günther S, Hensley L, Okogbenin S; Viral Hemorrhagic Fever Consortium., Schaffner SF, Okokhere PO, Khan SH, Grant DS, Akpede GO, Asogun DA, Gnirke A, Levin JZ, Happi CT, Garry RF, Sabeti PC.

Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone.

Cell. 2015.
Park DJ, Dudas G, Wohl S, Goba A, Whitmer SL, Andersen KG, Sealfon RS, Ladner JT, Kugelman JR, Matranga CB, Winnicki SM, Qu J, Gire SK, Gladden-Young A, Jalloh S, Nosamiefan D, Yozwiak NL, Moses LM, Jiang PP, Lin AE, Schaffner SF, Bird B, Towner J, Mamoh M, Gbakie M, Kanneh L, Kargbo D, Massally JL, Kamara FK, Konuwa E, Sellu J, Jalloh AA, Mustapha I, Foday M, Yillah M, Erickson BR, Sealy T, Blau D, Paddock C, Brault A, Amman B, Basile J, Bearden S, Belser J, Bergeron E, Campbell S, Chakrabarti A, Dodd K, Flint M, Gibbons A, Goodman C, Klena J, McMullan L, Morgan L, Russell B, Salzer J, Sanchez A Wang D, Jungreis I, Tomkins-Tinch C, Kislyuk A, Lin MF, Chapman S, MacInnis B, Matthews A, Bochicchio J, Hensley LE, Kuhn JH, Nusbaum C, Schieffelin JS, Birren BW, Forget M, Nichol ST, Palacios GF, Ndiaye D, Happi C, Gevao SM, Vandi MA, Kargbo B, Holmes EC, Bedford T, Gnirke A, Ströher U, Rambaut A, Garry RF, Sabeti PC.

A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection.

Mol Cell Proteomics. 2013.
Lin AE, Greco TM, Döhner K, Sodeik B, Cristea IM.

Click here for a full publication list.

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