Ryan Tewhey is a postdoctoral fellow in the Sabeti lab. His primary focus is on the development of high-throughput screening systems to understand the functional impact of non-coding polymorphisms. He is currently applying the massively parallel reporter assay (MPRA) and large scale CRISPR based screens against non-coding regions of the genome to identify causal alleles driving loci identified from genome wide association studies. His broad interests lie in the application of novel technologies to answer questions related to human health and disease. His time is evenly divided between wet and dry lab approaches.
Ryan completed a dual major in Cellular Biology and Biochemistry at the University of Maine, Orono and then worked for two years at the Broad Institute assisting with the first genome wide association studies for type II diabetes. He received his PhD from the University of California, San Diego in 2012 while carrying out work at The Scripps Research Institute. Here he developed technologies to enable high-throughput sequencing studies and used the technologies to study human complex diseases as well as microbial pathogenesis. He was named to Forbes Magazine’s 30 under 30 in science in 2011, has conducted research at the Genome Institute of Singapore as a NSF/A-STAR EAPSI fellow and was awarded the American Society of Human Genetics Charles J. Epstein Trainee Award for Excellence in Human Genetics Research in 2016. He is currently supported by a Pathway to Independence award (K99) from the NIH.