Sharif Tabebordbar – Sabeti Lab

SHARIF TABEBORDBAR, Ph.D.

Sharif Tabebordbar is a supervisor, research scientist in the Sabeti lab. Sharif’s research is focused on engineering adeno-associated viruses (AAVs) to develop tissue-specific gene delivery vehicles and to improve safety of AAV-mediated gene delivery for gene editing applications.

Sharif received his BSc and MSc degrees in biotechnology from University of Tehran and his Ph.D. in Developmental and Regenerative Biology from Harvard University. During his Ph.D., he developed culture conditions to expand healthy and diseased adult muscle stem cells in culture and provided the proof of concept for correcting the genetic mutation in these cells using gene editing technology. He also provided evidence for the feasibility of an in vivo gene editing-based approach to treat Duchenne Muscular Dystrophy (DMD) and investigated the host immune response after delivery of gene editing components into animals. The results of his research have been published in several peer-reviewed journals including Cell, Science, and Nature Methods.

Sharif is the recipient of Distinction in Teaching Award from Derek Bok Center for Teaching and Learning at Harvard, Albert J. Ryan Foundation Award for Outstanding Graduate Students in Biomedical Sciences, Excellence in Research Award and Career Development Award from American Society of Gene and Cell Therapy and Royan International Research Award in Regenerative Medicine. In 2020, Sharif was listed as a finalist (top 100) in the MIT 35 innovators under 35 competition.

SELECTED PUBLICATIONS

In Situ Modification of Tissue Stem and Progenitor Cell Genomes.

Cell Reports. 2019.
Goldstein J, Tabebordbar M, Zhu K, Wang L, Messemer K, Peacker B, Ashrafi Kakhki S, Gonzalez-Celeiro M, Shwartz Y, Cheng J, Xiao R, Barungi T, Albright C, Hsu Y, Wagers A, Equally contributed.

Genome Editing in Neurosciences.

Research and Perspectives in Neurosciences. Springer. 2017.
Tabebordbar M, Cheng JKW, Wagers AJ.

In vivo Gene Editing in Dystrophic Mouse Muscle and Muscle Stem Cells.

Science. 2016.
Tabebordbar M, Zhu K, Cheng JKW, Chew WL, Widrick JJ, Yan WX, Maesner C, Wu EY, Xiao R, Ran FA, Cong L, Zhang F, Vandenberghe LH, Church GM, Wagers AJ. *Equally contributed.

A Multifunctional AAV-CRISPR-Cas9 and its Host Response.

Nature Methods. 2016.
Chew WL, Tabebordbar M, Cheng JK, Mali P, Wu EY, Ng AH, Zhu K, Wagers AJ, Church GM. *Equally contributed.

A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species.

Cell. 2013.
Xu C, Tabebordbar M, Iovino S, Ciarlo C, Liu J, Castiglioni A, Price E, Liu M, Barton ER, Kahn CR, Wagers AJ, Zon LI. Equally contributed.

Modified mRNA Directs the Fate of Heart Progenitor Cells and Induces Vascular Regeneration after Myocardial Infarction.

Nature Biotechnology. 2013.
Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR.

Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment.

Cell 2013.
Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA, Steinhauser ML, Ding H, Butty VL, Torrey L, Haas S, Abo R, Tabebordbar M, Lee RT, Burge CB, Boyer LA.

Skeletal Muscle Degenerative Diseases and Strategies for Therapeutic Muscle Repair.

Annual Review of Pathology: Mechanisms of Disease. 2013.
Tabebordbar M, Wang ET, Wagers AJ.

Click here for a full publication list.

SHARIF TABEBORDBAR, Ph.D.

SELECTED PUBLICATIONS

Cell Reports. 2019. Goldstein J*, Tabebordbar M*, Zhu K*, Wang L, Messemer K, Peacker B, Ashrafi Kakhki S, Gonzalez-Celeiro M, Shwartz Y, Cheng J, Xiao R, Barungi T, Albright C, Hsu Y, Wagers A, * Equally contributed.

Research and Perspectives in Neurosciences. Springer. 2017. Tabebordbar M, Cheng JKW, Wagers AJ.

Science. 2016. Tabebordbar M*, Zhu K*, Cheng JKW, Chew WL, Widrick JJ, Yan WX, Maesner C, Wu EY, Xiao R, Ran FA, Cong L, Zhang F, Vandenberghe LH, Church GM, Wagers AJ. *Equally contributed.

Nature Methods. 2016. Chew WL*, Tabebordbar M*, Cheng JK, Mali P, Wu EY, Ng AH, Zhu K, Wagers AJ, Church GM. *Equally contributed.

Cell. 2013. Xu C*, Tabebordbar M*, Iovino S*, Ciarlo C, Liu J, Castiglioni A, Price E, Liu M, Barton ER, Kahn CR, Wagers AJ, Zon LI. *Equally contributed.

Nature Biotechnology. 2013. Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR.

Cell 2013. Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA, Steinhauser ML, Ding H, Butty VL, Torrey L, Haas S, Abo R, Tabebordbar M, Lee RT, Burge CB, Boyer LA.

Annual Review of Pathology: Mechanisms of Disease. 2013. Tabebordbar M, Wang ET, Wagers AJ.