The Broad Institute is the Sabeti Lab's second home. Dr. Sabeti is an Institute Member of the Infectious Disease Initiative, and we work with researchers and staff from all of the Broad's programs and scientific platforms. In particular, we rely on our collaborators at the Broad for genome sequencing and analysis.
In our work studying genetic susceptibility to Lassa, we have established strong collaborations with outstanding partners in Nigeria. Dr. Christian Happi, with whom we have worked for years on malaria, runs a thriving research program at Redeemer's University.
Founded in 2014, the African Center of Excellence for the Genomics of Infectious Disease, is centered at Redeemer’s University, Nigeria and led by Dean of Graduate Studies, Dr. Christian Happi. ACEGID, which includes several university and hospital partners in Nigeria, Sierra Leone, Senegal, and the U.S., is committed to the development of sustainable scientific careers in Africa in the field of genomics. Over the next five years, ACEGID has a mandate to establish lasting scientific capacity in genomics through complementary education¬-based and research goals related to the detection and control of infectious diseases. ACEGID is supported by the World Bank and the NIH H3Africa program. More information can be found at www.acegid.org.
The Irrua Specialist Teaching Hospital (ISTH) in Irrua, Nigeria, is an ideal location for our study. The hospital, with its 140 physicians and ~16,000 annual patients, is located in a rural area in Nigeria where Lassa is endemic with yearly outbreaks. The hospital has a commitment to research and has collaborated with researchers at the Berhnardt-Nocht Institute (BNI) in Hamburg in one of the best recent epidemiological studies on Lassa.
We work alongside collaborators from the Garry Lab at the Tulane School of Medicine studying Lassa fever.
Kenema Government Hospital
Sierra Leone
The Kenema Government Hospital is located 300km east of Freetown, in Kenema, Eastern Province, Sierra Leone, an area with the highest incidence of Lassa Fever in the world. Sierra Leone endured a bloody civil war for over a decade prior to its end in 2002, but the newfound peace in the region has made it possible to re-establish and expand the biomedical infrastructure, and continue Lassa Fever research in this region.
The Sabeti Lab is part of the Viral Hemorrhagic Fever Consortium, a partnership of research institutes whose mission is to promote global health and safety by creating new products to diagnose, treat, and significantly reduce the incidence and mortality rate of viral hemorrhagic fevers.
Collaborating with Fudan University in China, we are carrying out large-scale population studies to pursue the underlying biological significance of the signals of positive selection in East Asian populations.
Fathom Information Design is a Boston-based company specializing in data visualization software. We are working with Fathom on the development of tools to understand biological and epidemiological data.
We work with researchers at USAMRIID studying the genetic indicators of susceptibility and resistance to infectious diseases like Lassa fever and Ebola.
The International Centre for Diarrhoeal Disease Research, Bangladesh, is a leading health research institution located in Dhaka, the historic epicenter of cholera.
Massachusetts Department of Public Health
We work with the Massachusetts Department of Public Health to analyze and inform response to outbreaks in our own backyard.
