The goals of the Sabeti lab are to use computational methods and genomics to understand mechanisms of evolutionary adaptation in humans and pathogens. We are pursuing these goals through 3 research foci: (1) developing analytical methods to detect and investigate natural selection in the genome of humans and other species, (2) pursuing signals of natural selection in humans to identify their underlying functional trait and the mechanism of evolution (e.g resistance to Lassa fever virus), and (3) examining signals of natural selection in pathogens to understand how they rapidly evolve to remain agents of human morbidity and mortality.
