Colleagues – Sabeti Lab

Abudayyeh-Gootenberg Lab (MIT)

Omar Abudayyeh and Jonathan Gootenberg

The AbuGoot lab combines natural biological discovery and molecular engineering to develop a suite of new tools for manipulation of DNA, RNA, and cellular states — the cellular engineering toolbox. We are applying these tools to contexts such as cellular fate, aging, and genetic disease. We are looking for new team members, including research associates, graduate students, and postdoctoral fellows, to join our dynamic group.

Baum Lab (Imperial)

Jake Baum

jake.baum@imperial.ac.uk

If you are bright, ambitious and have a strong CV, you may well be in the running for a postdoctoral research fellowship and, if you click with the lab, we’re always willing to pull out the stops to help you get funded. We’re particularly keen on applications from students or post-doctoral scientists with skills outside the box from computational biology, math, physical sciences, engineering or chemistry. We’ll teach you how to be a cellular parasitologist, you teach us how to think differently!

Capellini Lab (Harvard)

Terry Capellini

tcapellini@fas.harvard.edu

The Capellini Lab at Harvard University has a post-doctoral position available starting early summer. The lab is looking for someone interested in studying the genetic and developmental basis of human-specific adaptations and disease. While the lab primarily concentrates on skeletal adaptations in humans and primates, an important research focus is to identify causal genetic variants that mediate human phenotypes resulting from more recent selection. The lab uses a variety of experimental and computational tools, such as functional genomics (e.g., ATAC-seq), developmental genetics in the mouse (e.g., CRISPR-Cas9), and in vitro methods on human cells, to explore the consequences of genetics variants on human biology. Promising doctoral students finishing theses this spring who are looking for a post-doctoral fellowship should contact the P.I. Terence Capellini.

Cotsapas Lab (Yale)

Chris Costapas

costapas@broadinstitute.org

Fenno Lab (UT Austin)

Lief Fenno

lief.fenno@austin.utexas.edu

The Fenno lab at the University of Texas Austin works at the intersection of molecular/viral engineering, neuroscience, and psychiatry, to develop and apply novel strategies to manipulate targeted neural circuits for both basic and translational application. On-going work includes (engineering) AAV payload and targeted delivery optimization, and development of genetically encoded synaptic gain modulators; (biology) characterizing the role of gliotransmitters and opioid neuropeptides in shaping cortical information flow across neural circuits, with relevance to human psychiatric illness. The lab is funded by the Clayton Foundation for Research, The W.M. Keck Foundation, the BD2 Foundation, and the State of Texas STARs fund. Lief Fenno, MD, PhD is a psychiatrist and neuroscientist who developed optogenetic tools and multiplexed AAV delivery strategies with Karl Deisseroth at Stanford University and applied these to causally investigate neural phenomena from human patients with Autism, Schizophrenia, and Anxiety. The group welcomes scientists from diverse backgrounds, is largely international, and is able to support visa needs.

Keywords: AAV, gene therapy, molecular tool development, neuroscience, and psychiatry/neurology.

Human Evolutionary Genetics, Department of Genomes and Genetics, UMR: Evolutionary Genomics, Modeling and Health

Lluis Quintana-Murci

lluis.quintana-murci@pasteur.fr

Lieberman Lab (Harvard)

Tami Lieberman

tami@mit.edu

In the Lieberman lab at MIT, we develop and apply new genomic and experimental methods to understand colonization within the human microbiome and to accelerate the development of rational microbiome-based therapies. We study within-person evolution and diversification of the microbiome, identify genes crucial to colonization, and track the transmission of microbes between and within people. Current projects include studying the role of phage and interbacterial warfare in the gut microbiome, assessing the ability of new Propionibacterium acnes strains to colonize children during puberty, studying the adaptation of S. aureus to eczema lesions, and developing new computational approaches for strain-level identification in metagenomic data. We are recruiting ambitious postdocs and graduate students from a wide variety of disciplines.

Oldstone Lab (Scripps)

Michael Oldstone

mbaobo@scripps.edu

Competitive postdoctoral position open for the Viral Immunobiology Laboratory at The Scripps Research Institute, La Jolla, California. Molecular and cell biologic training in pathogenesis of arenaviruses. Projects build on the laboratory’s discovery and expertise in manipulation of the genes of arenaviruses Lassa and lymphocytic choriomeningitis and the cell receptor (alpha-dystroglycan modified by the glycosyltransferase LARGE) for these viruses. Goals being understanding selection for resistance or susceptibility to these viruses in humans and mice, using high throughput assays to develop therapeutics, utilizing inducible pleuri potent cells so that viral binding, entry and infection occurs in relevant differentiated cells containing the mutation in virus receptor in humans discovered by the Sabeti laboratory. Interested applications should consult pub med for publications by Michael Oldstone and by Juan Carlos de la Torre.

Sherwood Lab (Harvard Medical School)

Rich Sherwood

rsherwood@rics.bwh.harvard.edu

The Sherwood lab’s main focus is in using genome editing screens combined with computational approaches to understand the genome and develop gene therapy approaches. We develop new high-throughput screening platforms to understand and treat diseases with a genetic component and are always looking for creative thinkers from a range of backgrounds to contribute to our interdisciplinary efforts.

Sidow Lab (Stanford)

Arend Sidow

stanfordcancerevolution@gmail.com

The Stanford BRCA Collaborative (PIs Batzoglou, Ford, Sidow, West) is seeking an exceptional computational Postdoc to be part of our cancer genomics and evolution research. Please apply if you are fascinated by how the cancer genome functions and evolves, and if you have deep computational experience in creative analyses of large genomic datasets (not necessarily cancer). We are scaling up and will be generating significant amounts of data in the next few years. Your mission will be to help found the effort by creating lasting computational infrastructure (computational genomics pipelines and methods) and spearheading analyses, on both WGS and functional genomic data. There is opportunity to help design the data generation so as to be most informative on the process of cancer genome evolution. Apply! Stanford is amazing and the team is awesome. If interested, please email stanfordcancerevolution@gmail.com with your CV and research statement.