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JACOB LEMIEUX, M.D., D.Phil.

Jacob.lemieux

Jacob Lemieux was a post-doctoral researcher in the Sabeti Lab and is an infectious diseases staff physician at Massachusetts General Hospital. He holds a B.S. from Stanford University, a D.Phil. in molecular parasitology from Oxford University, where he was a Rhodes Scholar and member of the NIH-Oxford Graduate Partnership Program, and an M.D. from Harvard Medical School. He is interested in the genetics and pathophysiology of red blood cell parasites, tick-borne diseases, and respiratory viruses.

“The Lemieux lab integrates computational and experimental studies of microbial genetic variation to understand how pathogens spread in the population and cause disease in human hosts. Our studies focus on Borrelia burgdorferi, the bacterial agent of Lyme disease, and SARS-CoV-2, the cause of COVID-19. Major projects in the lab include the use of computational screens and genome-wide association studies to identify microbial genes associated with disease phenotypes, for both Lyme disease and COVID-19, followed by the use of reverse genetic tools to characterize mechanisms of disease-associated loci in experimental systems.”

SELECTED PUBLICATIONS

A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapse.

Nat Microbiol. 2016.
Lemieux JE, Tran AD, Freimark L, Schaffner SF, Goethert H, Andersen KG, Bazner S, Li A, McGrath G, Sloan L, Vannier E, Milner D, Pritt B, Rosenberg E, Telford S, Bailey JA, Sabeti PC.

Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation.

Mol Microbiol. 2013.
Lemieux JE, Kyes SA, Otto TD, Feller AI, Eastman RT, Pinches RA, Berriman M, Su XZ, Newbold CI.

Statistical estimation of cell-cycle progression and lineage commitment in Plasmodium falciparum reveals a homogeneous pattern of transcription in ex vivo culture.

PNAS USA. 2009.
Lemieux JE*, Gomez-Escobar Nm Feller A, Carret C, Amambua-Ngwa A, Pinches R, Day F, Kyes SA, Conway DJ, Holmes CC, Newbold CI.

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