Katie Siddle is a postdoctoral fellow at Harvard University and the Broad Institute, where she is interested in the evolution of viral pathogens, host-pathogen interactions and the etiology of uncharacterized infections.
In her research Katie combines developing methods to improve the detection and assembly of viral genomes and active surveillance for emerging infections, with a particular focus on West Africa. Recently, Katie jointly developed and validated a novel tool to design optimized probe sets to enrich diverse viral sequences, improving the sensitivity of high-throughput sequencing. Katie also works closely with partners in Senegal and Nigeria to implement these technologies locally and study emerging infections in these regions. As part of this, Katie co-led a study of the genomic epidemiology of the 2018 Lassa virus outbreak in Nigeria. She is also studying other viral pathogens including Yellow fever virus and Dengue virus in West Africa to understand their diversity and detect biomarkers of infection.
Katie obtained her Ph.D. in human immunogenomics from the Institut Pasteur and the Université Pierre et Marie Curie in Paris, France, under Lluis Quintana-Murci. Her doctoral work focused on microRNA regulation in the human innate immune response to infection, where she performed the first study of the impact of external stimuli on the genetic regulation of microRNA expression and the first demonstration of consistent changes in microRNA isoform expression in response to infection. Katie was a fellow of the Pasteur-Paris University International Doctoral Program. Prior to this, Katie completed her BA and MPhil in Biological Anthropology at the University of Cambridge, UK, where she studied the genetic ancestry of indigenous populations in the Philippines.
Katie is the recipient of postdoctoral fellowships from Human Frontiers in Science Program (HFSP) and the Fondation pour la Recherche Médicale (FRM). Her work is currently supported by the American Society for Tropical Medicine and Hygiene (ASTMH) Centennial Award.