• Home
  • Research
    • Projects
    • Publications
  • Outreach
    • Equity and Outreach
      • Education
    • Holiday Card
    • Videos
  • Team
    • Team
    • Alumni
    • Collaborators
    • Opportunities
  • Giving
Sabeti Lab Sabeti Lab
  • Home
  • Research
    • Projects
    • Publications
  • Outreach
    • Equity and Outreach
      • Education
    • Holiday Card
    • Videos
  • Team
    • Team
    • Alumni
    • Collaborators
    • Opportunities
  • Giving

KAYLA BARNES, Ph.D.

Kayla.Barnes.adjustweb

Kayla Barnes is a NIH Fogarty K fellow at the Harvard School of Public Health and Broad Institute. In the Sabeti lab her work focuses on evolutionary genetics of both humans and pathogens. Kayla is a co-leader on two genome-wide association studies of susceptibility to Ebola Virus Disease and Lassa fever as well as numerous other projects exploring viral genetics and single cell genomics. Kayla has also developed cutting edge CRISPR based diagnostics for viruses causing hemorrhagic fever and severe diarrheal diseases. In addition to her current work, Kayla has published studies on the 2018 Lassa Fever outbreak in Nigeria and Ebola persistence in semen. Kayla’s postdoctoral work is supported by a NIH-K01, ASTMH Shope fellowship, Bill and Melinda Gates Foundation funding, and a Broad-Next 10 grant.

Kayla carried out her Ph.D. in Tropical Medicine at the Malawi-Liverpool Wellcome Trust Center in Blantyre, Malawi, and the Liverpool School of Tropical Medicine with Janet Hemingway and Charles Wondji. Her work led to a better understanding of the genomics and evolutionary genetics driving insecticide resistance mechanisms in a main malaria mosquito vector throughout southern Africa. Kayla was awarded the Jean Clayton Fellowship and the ASTMH Young Investigator Award for her Ph.D. work.

Before Kayla’s Ph.D. she worked for Dyann Wirth at the Harvard School of Public Health, where she studied multiplicity of Plasmodium falciparum infection, and helped analyze geographical variation and antimalarial drug resistance in P. falciparum isolates. Kayla completed her undergraduate degree in Evolutionary Biology and Chemistry at the University of Colorado. Kayla was an Undergraduate Research Opportunity (UROP) recipient and studied haptoglobin polymorphisms in endurance athletes under Jeffry Mitton.

SELECTED PUBLICATIONS

First/Co-First Publications

*Denotes starred first authors that contributed equally to this paper, §Denotes corresponding authors

Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018

New England Journal of Medicine. 2018, Nov 1; 379
Siddle KJ, Eromon P*, Barnes KG*§, Mehta S*, Oguzie JU*, Odia I*...… MacInnis BL*, Sabeti PC*, Happi CT*§.

Evidence of Ebola Virus Replication and High Concentration in Semen of a Patient During Recovery.

Clinical Infectious Diseases. 2017, Oct 15; 65(8)
Barnes KG*, Kindrachuk J*, Lin AE*, Wohl S, Qu J, Tostenson SD, Dorman WR, Busby M, Siddle KJ, Luo CY, Matranga CB, Davey RT, Sabeti PC, and Chertow DS§.

Africa-wide selective sweep of pyrethroid genes correlates with scaling up of malaria control.

Plos Genetics. 13 (2): e1006539
Barnes KG*, Weedall G*, Ndula M, Irving H, Mzilahowa T, Hemingway J, Wondji CS§.

Restriction to gene flow is linked to changes in the molecular basis of pyrethroid resistance in the malaria vector Anopheles funestus.

PNAS. 2016, Nov 11; 114(2).
Barnes KG, Irving H, Chiumia M, Mzilahowa T, Coleman M, Hemingway J, Wondji CS§.

Selected Co-Author Publications

*Denotes starred first authors that contributed equally to this paper.

Capturing diverse microbial sequence with comprehensive and scalable probe design.

Nature. 2019, Feb; 37(2).
Metsky HC*, Siddle KJ*… Barnes KG … Sabeti PC*, Matranga CB*.

Field-deployable viral diagnostics using CRISPR-Cas.

Science. 2018, Apr 27; 360(6387).
Myhrvold C*, Freije CA*, Jonathan S. Gootenberg JS, Abudayyeh OO, Metsky HC, Durbin AF, Kellner MJ, Tan AL, Paul LM, Parham LA, Garcia KF, Barnes KG, Chak B, Mondini A, Nogueira ML, Isern S, Michael SF, Lorenzana I, Yozwiak NL, MacInnis BL, Bosch I, Gehrke L, Zhang F, and Sabeti PC.

Ebola Virus Persistence in Ocular Tissues and Fluids (EVICT) Study: Reverse Transcription-Polymerase Chain Reaction and Cataract Surgery Outcomes of Ebola Survivors in Sierra Leone.

Ebio Medicine. 2017, Apr 30.
Shantha JG, Mattia JG, Goba A, Barnes KG, … Garry RF, Vandy M, Yeh S.

Zika virus evolution and spread in the Americas.

Nature. 2017, May 24.
Metsky HC, Matranga CB, Wohl S, Schaffner SF, … Barnes KG … Isern S, Michael SF, Bozza FA, Souza TML, Bosch I, Yozwiak NL, MacInnis BL, Sabeti PC.

Genomic epidemiology reveals multiple introductions of Zika virus into the United States.

Nature. 2017, May 24.
Grubaugh ND, Ladner JT, Kraemer MUG, Dudas G, Tan AL, …. Barnes KG …. Rambaut A, Sanchez-Lockhart M, Sabeti PC, Gillis LD, Michael SF, Bedford T, Pybus OG, Isern S, Palacios G, Andersen KG.

Partners in crime: the highly polymorphic CYP6M7 cytochrome P450 gene combines with the directionally selected CYP6P9a and CYP6P9b genes to expand the pyrethroid resistance front in the malaria vector Anopheles funestus in Africa.

BMC Genomics. 2014, 15:817.
Riveron JM*, Ibrahim SS*, Chanda E, Mzilahowa T, Cuamba N, Irving H, Barnes KG, Ndula M, Wondji CS.

Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus.

PNAS. 2013, Jan 2;110(1).
Riveron JM, Irving H, Ndula M, Barnes KG, Ibrahim SS, Paine MJI, Wondji CS.

Impact of pyrethroid resistance on operational malaria control in Malawi.

PNAS. 2012, Nov 20;109(47):19063-70
Wondji CS*, Coleman M*, Kleinschmidt I, Mzilahowa T, Irving H, Ndula M, Rehman A, Morgan J, Barnes KG, Hemingway J.

Hybrid selection for sequencing pathogen genomes from clinical samples.

Genome Biology. 2011, 12(8):R73.
Melnikov A, Galinsky K, Rogov P, Fennell T, Van Tyne D, Russ C, Daniels R, Barnes KG, Bochicchio J, Ndiaye D, Sene PD, Wirth DF, Nusbaum C, Volkman SK, Birren BW, Gnirke A, Neafsey DE.

Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.

PLoS Genetics. 2011, v7:4.
Van Tyne D, Park DJ, Schaffner SF, Neafsey DN, Angelino E, Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA, Johnson CA, Shlyakhter I, Grossman SR, Becker JS, Yamins D, Karlsson EK, Ndiaye D, Sarr O, Mboup S, Happi C, Furlotte NA, Eskin E, Kang HM, Hartl DL, Birren BW, Wiegand RC, Lander ES, Wirth DF, Volkman SK, Sabeti PC.

Contact Us

Send us an email and we'll get back to you, asap.

Send Message

Navigation

Home
Research
Outreach
Team
News
Pardis

Location

  • Broad Institute of MIT and Harvard
  • 415 Main Street, Cambridge, Massachusetts 02142

Community

Recent Tweets

News

  • Pardis interviews with HuffPost Entertainment
  • Watch Pardis’ TED talk!
  • Sabeti Lab researchers publish paper on Lassa virus in Cell
  • Mahan Nekoui, undergrad in the lab, has been named one of top 20 under 20 by Plan Canada
  • Sabeti Lab Researchers Publish Analysis of Ebola Virus
  • Dr. Sabeti announced as HHMI investigator
Read the blog!

© 2022 — sabetilab.org

  • Careers
  • Team
  • Collaborators
  • Education
  • Publications
  • Research
  • Giving